Their meeting at Elland Road will be the first time the two teams have met in the Premier League since 2004, but there have been other clashes in the years since.
The most memorable for Leeds fans is undoubtedly the 1-0 FA Cup upset at Old Trafford in 2010, with Jermaine Beckford scoring the decisive goal.
Click and scroll through to see what the Whites’ lineup from that day are up to now:
1. Casper Ankergren
The Dane left Elland Road in at the end of the 2009/10 campaign, moving to Brighton and Hove Albion. Ankergren ended his career on the south coast in 2017, and has been working as a goalkeeping coach for the Seagulls ever since. (Photo by Shaun Botterill/Getty Images) Photo: Shaun Botterill
2. Jason Crowe
A former England youth international and product of Arsenal's youth system, Crowe never really lived up to his early potential. After leaving Leeds in 2011, he had spells at Leyton Orient and Northampton Town, before hanging up his boots at non-league Corby Town. (Photo by Alex Livesey/Getty Images) Photo: Alex Livesey